ObjectiveThe presence of two or more chronic diseases results in worse clinical outcomes than expected by a simple combination of diseases. This synergistic effect is expected to be higher when combined with some conditions, depending on the number and severity of diseases. Multimorbidity is a relatively new term, with the first fundamental definitions appearing in 2015. Studies usually define it as the presence of at least two chronic medical illnesses. However, little is known regarding the relationship between mental disorders and (...) other non-psychiatric chronic diseases. This review aims at investigating the association between some mental disorders and non-psychiatric diseases, and their pattern of association.MethodsWe performed a systematic approach to selecting papers that studied relationships between chronic conditions that included one mental disorder from 2015 to 2021. These were processed using Covidence, including quality assessment.ResultsThis resulted in the inclusion of 26 papers in this study. It was found that there are strong associations between depression, psychosis, and multimorbidity, but recent studies that evaluated patterns of association of diseases had heterogeneous results. Quality assessment of the papers generally revealed low quality among the included studies.ConclusionsThere is evidence of an association between depressive disorders, anxiety disorders, and psychosis with multimorbidity. Studies that tried to examine the patterns of association between diseases did not find stable results.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021216101, identifier: CRD42021216101. (shrink)

La dernière fois que j’ai vu Claude, il était chez lui, dans l’appartement parisien surchauffé. Il y régnait une atmosphère de fin du monde, et j’allais comprendre qu’en effet, la fin d’un monde était advenue, d’un monde qui avait été celui de Claude jusqu’à ses dernières semaines. Un monde vécu dans l’optimisme irréductible qui le caractérisait, confiant en quelque sorte dans le contexte français. Vanilda, son épouse, était alitée après une opération de l’épaule, cassée suite..

В книге продолжается обсуждение тем, представленных в труде "Психология нравственности", изданном в 2010 году. Авторы обсуждают пути решения проблем и преодоления переживаемого нашим обществом глубокого нравственного кризиса.

Издание содержит: теоретические основания субъектного подхода в психологии; основные направления психологического анализа; экспериментальные исследования психологии субъекта и др.

Recent preclinical studies have shown the feasibility of specific variants of nuclear transfer to prevent mitochondrial DNA disorders. Nuclear transfer could be a valuable reproductive option for carriers of mitochondrial mutations. A clinical application of nuclear transfer, however, would entail germ-line modification, more specifically a germ-line modification of the mitochondrial genome. One of the most prominent objections against germ-line modification is the fear that it would become possible to alter ‘essential characteristics’ of a future person, thereby possibly violating the child's (...) right to an open future. As only the nuclear DNA would contain the ingredients for individual characteristics, modification of the mtDNA is often considered less controversial than modification of the nuclear DNA. This paper discusses the tenability of this dichotomy. After having clarified the concept of germ-line modification, it argues that modification of the mtDNA is not substantively different from modification of the nuclear DNA in terms of its effects on the identity of the future person. Subsequently the paper assesses how this conclusion affects the moral evaluation of nuclear transfer to prevent mtDNA disorders. It concludes that the moral acceptability of germ-line modification does not depend on whether it alters the identity of the future child—all germ-line modifications do—but on whether it safeguards the child's right to an open future. If nuclear transfer to prevent mtDNA disorders becomes safe and effective, then dismissing it because it involves germ-line modification is unjustified. (shrink)

It is important to recognize that the problem dealt with by Plato in the central part of the Sophist is one which arises from the use of certain Greek phrases, and has no necessary or direct connexion with metaphysics. We tend to obscure this fact if we use English terms such as ‘Being’, ‘Reality’, ‘Existence’, etc., in discussing the dialogue, and indeed make it almost impossible to understand what Plato is trying to do. It is the way in which die (...) Greek terms ỗν and μή ỗν and other such terms are used by the ‘sophists’ which gives rise to the problem. (shrink)

Randomised clinical trials provide the most valid means of establishing the efficacy of clinical therapeutics. Ethical standards dictate that patients and clinicians should not consent to randomisation unless there is uncertainty about whether any of the treatment options is superior to the others ("equipoise"). However, true equipoise is rarely present; most randomised trials, therefore, present challenging ethical dilemmas. Minimising the tension between science and ethics is an obligation of investigators and clinicians. This article briefly reviews several techniques for addressing this (...) issue and suggests that unbalanced randomisation, a technique rarely employed in current clinical trial practice, may be useful for enhancing the ethical design of human experimentation. (shrink)

In the period of decolonisation that followed the end of the Second World War a number of scholars, mainly Middle Eastern, launched a sustained assault on Orientalism - the theory and practice of representing 'the Orient' in Western thought -accusing its practitioners of misrepresentation, prejudice and bias. As a result an intense debate occurred regarding the validity of the charges made, involving not only Orientalists but students of history, anthropology, sociology, women's studies and the media. Orientalism: A Reader provides the (...) student with a selection of key readings from this debate, covering a range of areas including myth, imperialism, the cultural perspective, Marxist interpretation and feminist attitudes.The origins and character of the debate on Orientalism are introduced, as well as the intellectual foundations of the assault made and the nature of the debate which ensued. Coverage begins with nineteenth-century material from thinkers such as Hegel and Marx, and moves through extracts from Nietzsche, Gramsci and Foucault to contemporary work from, for example, Bryan Turner, John MacKenzie and Edward Said. As well as a general introduction, each section is introduced and the extracts are placed in context to guide the student carefully through this complex debate. (shrink)

Tom 1. Rannekhristianskiĭ gnosticheskiĭ tekst v rossiĭskoĭ kulʹture (21 i︠a︡nvari︠a︡ 2011 g.) -- Tom 2. Sudʹby religiozno-filosofskikh iskaniĭ Nikolai︠a︡ Novikova i ego kruga (15-17 okti︠a︡bri︠a︡ 2012 g.).

This Reader explores the extent of Oriental influence on European thought, primarily in the period of the Enlightenment and the nineteenth-century period of doubt and scepticism that followed it. It is the first Reader to bring together in one place a series of specific historical and textual studies of Oriental influence upon European thinkers.

It is in the scholium of thePrincipiaon time, space, place and motion that Newton delivers what is — arguably — a reluctant kiss of betrayal to empiricism. Right there, ‘in the main body of his chief work,’ as E.A. Burtt observes, the deed is done: ‘When we come to Newton's remarks on space and time … he takes personal leave of his empiricism.’ Reichenbach registers the event less charitably, dismissing the ‘crude reification of space that Newton shares with the epistemologically (...) unschooled mind in its naive craving for realism.’ Injury is then added to insult as Reichenbach holds Newtonian mechanics to task for arresting the analysis of the problems of space and time for more than two centuries. (shrink)

The great number of contradictory statements which confront us when we examine the various explanations of Anaxagoras' philosophy make it more than usually important to decide what is to be admitted as first-hand evidence and what is not. I purpose, then, to begin by accepting the barest minimum of data, and I shall try to exclude any direct comments upon Anaxagoras' work by later writers. Sufficient justification for such a course may be found in the bewildering masses of confusion which (...) have gathered around his teaching. (shrink)

In attempting to realize the tasks facing Soviet philosophers today, at a crucial moment in the life of our society, and in an attempt to contribute as best we can to clearing up the intellectual atmosphere of the country, we turn again to the question of what philosophy is, what its place in the life of society is, and how it can and must develop. The present article is dedicated to an examination of one of the aspects of this complex (...) question. (shrink)

© The Authors 2017. Published by Oxford University Press on behalf of The Analysis Trust. All rights reserved. For Permissions, please email: journals.permissions@oup.comAndy Clark is usually among the first in philosophy to ride a new and important wave on the frontiers of cognitive science research. His Microcognition and Associative Engines chronicled connectionism, Being There explored embodied cognition, Natural Born Cyborgs deals with BCIs and environmental and technological scaffolding, and Supersizing the Mind is an extended argument for extended minds. Clark's latest, (...) showcases his new enthusiasm about predictive coding, a computational framework for understanding cognition that is generating more excitement and controversy across diverse areas of cognitive science than an offshore wind at Maverick’s does among the boarding elite....Clark is a master at taking complex ideas in cognitive science and conveying them in less technical fashion to a wide audience, doing so with panache and wit.... (shrink)

Discussion of the concept of evil in Indian philosophy.